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SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
USERS' SCORE
Good
Based on 14 Reviews
8.7
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Highly relevant for kidney stone treatment
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Vitamin B6 may lower kidney stones
Intake of vitamins B6 and C and the risk of kidney stones in women.
Focus on vitamin B6 effects
We examined the relationship between vitamin B6 intake and kidney stone formation in women. This research involved over 85,000 women with no prior history of kidney stones, monitored over 14 years. The study utilized food-frequency questionnaires to track participants' dietary vitamin consumption from both food and supplements.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Read More
8
Dietary magnesium may reduce stones
Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018.
Focus on magnesium's role
We wanted to understand the relationship between dietary magnesium intake and the prevalence of kidney stones. By examining data from the National Health and Nutrition Examination Survey spanning 2011 to 2018, we were able to analyze the self-reported history of kidney stones among participants.
Our findings indicated that those who consumed higher amounts of magnesium appeared to have a lower likelihood of experiencing kidney stones. Specifically, the average daily magnesium intake was lower in individuals with kidney stones, suggesting that magnesium might play a role in kidney stone formation.
In our analysis, we discovered that when grouped into different levels of magnesium intake, those in the highest intake category had significantly reduced odds of developing kidney stones compared to those in the lowest intake category. This trend suggests a protective effect of dietary magnesium against kidney stone disease.
While our results are promising, we recognize that further research is needed to determine if there is a direct causal relationship between magnesium intake and kidney stones. The evidence points towards a beneficial link, but more prospective studies will help clarify this important topic for better health outcomes.
Our findings indicated that those who consumed higher amounts of magnesium appeared to have a lower likelihood of experiencing kidney stones. Specifically, the average daily magnesium intake was lower in individuals with kidney stones, suggesting that magnesium might play a role in kidney stone formation.
In our analysis, we discovered that when grouped into different levels of magnesium intake, those in the highest intake category had significantly reduced odds of developing kidney stones compared to those in the lowest intake category. This trend suggests a protective effect of dietary magnesium against kidney stone disease.
While our results are promising, we recognize that further research is needed to determine if there is a direct causal relationship between magnesium intake and kidney stones. The evidence points towards a beneficial link, but more prospective studies will help clarify this important topic for better health outcomes.
Read More
Most Useful Reviews
10
Doctor's recommendation
Excellent for kidney stone prevention! My urologist recommended these tablets, citing studies that show B6 and Magnesium can prevent kidney stones in women. I’ve been taking them for 2-3 years, and they are absolutely fantastic! Although the recommended dosage is three tablets daily, I take only two, one in the morning and one in the evening with meals, and I haven’t had any issues with new stones.
Read More
9.5
Long-term relief
Something that WORKS! This product has kept my kidney stones at bay for decades. If you’ve got them, get this!
Read More
9.5
Muscle spasms
These tablets are excellent for muscle spasms. They are well-coated and easy to swallow, with no side effects. The absorption is quick, making them effective. I've found that the combination of B6 and magnesium is beneficial for kidney stones. I take up to three tablets daily with meals.
Read More
Most Recommended Products for Kidney Stones
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
9
Vitamin B6 may reduce stones
Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.
Moderate relevance to vitamin B6
The study examined the potential of pyridoxamine, a derivative of vitamin B6, in reducing kidney stones and oxalate excretion in conditions known as hyperoxaluria. The researchers aimed to find an effective treatment that would lower urine oxalate levels, which contribute significantly to kidney stone formation.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
Read More
9
Vitamin B6 aids in kidney stone prevention
[Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization].
Study relevant for kidney stone treatment
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
Read More
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Highly relevant for kidney stone treatment
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Vitamin B6 may prevent stones
Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.
Associates B6 with kidney health
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Read More
8
Vitamin B6 improves AGT function
Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay.
Significant findings on AGT variants
We explored the relationship between vitamin B6, also known as pyridoxine, and kidney stone formation, specifically in patients with primary hyperoxaluria type 1 (PH1). This condition arises from a deficiency in the enzyme alanine:glyoxylate aminotransferase (AGT), crucial for breaking down certain compounds in the liver. Among PH1 patients, about one-third have shown a clinical response to pharmacological doses of pyridoxine, especially those carrying specific AGT mutations.
To investigate this further, we utilized a cell-based cytotoxicity assay involving CHO cells expressing glycolate oxidase (GO) and various AGT variants. This setup allowed us to measure how well these AGT variants could counteract the toxic effects of glycolate, a compound that contributes to kidney stone formation. We observed that normal AGTs helped reduce the levels of harmful oxalate and glyoxylate, which are byproducts of glycolate, effectively improving cell survival.
Moreover, we found that increasing extracellular pyridoxine concentrations—up to 0.3μM—enhanced the metabolic effectiveness of normal AGTs and the variant AGT-Gly170Arg. This enhancement was associated with a significant reduction in oxalate and glyoxylate levels, directly linking vitamin B6's role to improved management of the metabolic processes involved in kidney stone formation.
Overall, our findings support the idea that vitamin B6 can improve the functionality of AGT, thus potentially offering a therapeutic route for managing PH1 and its associated kidney stone risks. This research not only enhances our understanding of PH1 but also opens avenues for developing better treatments for kidney stone diseases in general.
To investigate this further, we utilized a cell-based cytotoxicity assay involving CHO cells expressing glycolate oxidase (GO) and various AGT variants. This setup allowed us to measure how well these AGT variants could counteract the toxic effects of glycolate, a compound that contributes to kidney stone formation. We observed that normal AGTs helped reduce the levels of harmful oxalate and glyoxylate, which are byproducts of glycolate, effectively improving cell survival.
Moreover, we found that increasing extracellular pyridoxine concentrations—up to 0.3μM—enhanced the metabolic effectiveness of normal AGTs and the variant AGT-Gly170Arg. This enhancement was associated with a significant reduction in oxalate and glyoxylate levels, directly linking vitamin B6's role to improved management of the metabolic processes involved in kidney stone formation.
Overall, our findings support the idea that vitamin B6 can improve the functionality of AGT, thus potentially offering a therapeutic route for managing PH1 and its associated kidney stone risks. This research not only enhances our understanding of PH1 but also opens avenues for developing better treatments for kidney stone diseases in general.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.7
10
Doctor's recommendation
Excellent for kidney stone prevention! My urologist recommended these tablets, citing studies that show B6 and Magnesium can prevent kidney stones in women. I’ve been taking them for 2-3 years, and they are absolutely fantastic! Although the recommended dosage is three tablets daily, I take only two, one in the morning and one in the evening with meals, and I haven’t had any issues with new stones.
Read More
9.5
Muscle spasms
These tablets are excellent for muscle spasms. They are well-coated and easy to swallow, with no side effects. The absorption is quick, making them effective. I've found that the combination of B6 and magnesium is beneficial for kidney stones. I take up to three tablets daily with meals.
Read More
9.5
Convenient combination
I've been using these vitamins for years to combat kidney stones. It's great to have them combined in one pill, thus reducing my daily intake. They continue to work effectively for me.
9.5
Reliable aid
Works well and is easy to take. It helps with kidney stones, as I haven’t had an attack since I started using it.
9.5
Long-term relief
Something that WORKS! This product has kept my kidney stones at bay for decades. If you’ve got them, get this!
